Microfluidic multi-input reactor for biocatalytic synthesis using transketolase
نویسندگان
چکیده
منابع مشابه
Microfluidic multi-input reactor for biocatalytic synthesis using transketolase☆
Biocatalytic synthesis in continuous-flow microreactors is of increasing interest for the production of specialty chemicals. However, the yield of production achievable in these reactors can be limited by the adverse effects of high substrate concentration on the biocatalyst, including inhibition and denaturation. Fed-batch reactors have been developed in order to overcome this problem, but no ...
متن کاملMicrofluidic Reactor for Polymer Synthesis ! Polymer Synthesis within Microfluidic Reactor Microfluidic Rotary Pump
Conventional mechanical pumps based on centrifugal or axial turbomachinery are not suitable for micro and nano scales where the Reynolds numbers are usually small. Centrifugal and inertial forces are negligible, and viscous forces dominate the flow field in this length scale (an excellent review can be found on the physics of fluid flow at microscale in [1]). A microfluidic rotary pump, which i...
متن کاملCoin-Shaped Reactor in Microfluidic Devices Used for Radiopharmaceutical Synthesis
A microfluidic device has been designed and optimized for the multi-step synthesis of PET (Positron Emisssion Tomography) probes. Its PDMS elastomer-based architecture centered around a (5 L) coin-shaped reactor has novel features that facilitate mixing, solvent exchange, product collection and overall synthetic efficiency. New microfluidic properties and processes have been demonstrated in th...
متن کاملBiocatalytic Synthesis of Amino - Alcohols Using a de novo Designed Transketolase - P - Alanine : Pyruvate Transaminase Pathway in Escherichia coli
Biocatalysis continues to emerge as a powerful technique for the efficient synthesis of optically pure pharmaceuticals that are difficult to access via conventional chemistry. The power of a biocatalytic stage can be enhanced if two or more reactions can be achieved by a single whole cell biocatalyst containing a pathway designed de novo to facilitate a required synthetic sequence. This will al...
متن کاملBiocatalytic synthesis of vanillin.
The conversions of vanillic acid and O-benzylvanillic acid to vanillin were examined by using whole cells and enzyme preparations of Nocardia sp. strain NRRL 5646. With growing cultures, vanillic acid was decarboxylated (69% yield) to guaiacol and reduced (11% yield) to vanillyl alcohol. In resting Nocardia cells in buffer, 4-O-benzylvanillic acid was converted to the corresponding alcohol prod...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Molecular Catalysis B: Enzymatic
سال: 2013
ISSN: 1381-1177
DOI: 10.1016/j.molcatb.2013.05.016